Basic Information
VIS ID
TVIS30000315
Fusion event
HIV-ARHGEF17 integration
Validated
No
Detection method
NG-SGS
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30024859
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
73038581/73327536 (Hg38)
End
73038581/73327536 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
ARHGEF17
miRNAs that regulate target gene
hsa-mir-452-3p ; hsa-mir-4666a-5p ; hsa-mir-4320 ; hsa-mir-4708-3p ; hsa-mir-2276-3p ; hsa-mir-4772-3p ; hsa-mir-7153-3p ; hsa-mir-361-3p ; hsa-mir-5685 ; hsa-mir-4690-3p ; hsa-mir-6834-3p
Nearest miRNA
hsa-mir-10392/Upstream/543944; hsa-let-7a-2/Downstream/1071701;
Nearest TSS
ENST00000527297/Upstream/15971; ENST00000536170/Downstream/15388;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/18018, chr11-CpG: 73/Downstream/15067
Upstream sequence
CAAGTGTTGGCAGGAGAAAGACTGAGCTCTGAGGCTGGCAGGTCTGAGGCCCTTCAGGACCTAGGCCTTGCCCCGCTTAGTAGACCAGCCTGCCTGGTCC
Downstream sequence
ACCATACAGCCTAAGCTCCCACTTCTTTGGCCACGAAAAAtgtagaatgagtaggaagttgccaaacatagacataggaagccacacctggcagagagac
Reference
Sharaf, R., et al.HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers. J Clin Invest,2018,128(9): 4074-4085.
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