Basic Information
VIS ID
TVIS30000342
Fusion event
HIV-ZNRF1 integration
Validated
No
Detection method
NG-SGS
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30024859
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr16
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
75044510/75010612 (Hg38)
End
75044510/75010612 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNRF1
miRNAs that regulate target gene
hsa-mir-15b-5p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-4720-3p ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-6746-3p ; hsa-mir-6838-5p ; hsa-mir-4690-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-3194-5p ; hsa-mir-6849-3p ; hsa-mir-4691-3p ; hsa-mir-6858-3p
Nearest miRNA
hsa-mir-1225/Upstream/4980190; hsa-mir-11401/Downstream/1858324;
Nearest TSS
ENST00000527434/Upstream/8315; ENST00000579084/Downstream/84532;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/10303, chr16-CpG: 41/Downstream/103888
Upstream sequence
ggataatttttggagaaatttcacttcgtatttaggtatgtatggTCTCTCATCTTGGTCTTGGTGAATCAGACTTGTCATAGGAGTGCTCCAACTTTCT
Downstream sequence
TGTTGGTAGTAGCTTGAGCCCTCTGAAAAGTAATTAATCCATACTTCATAAAGAGTTGTTCTGAAATTAGTCACCTCTGTACTGTACTGTttttttttgt
Reference
Sharaf, R., et al.HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers. J Clin Invest,2018,128(9): 4074-4085.
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