Basic Information
VIS ID
TVIS30000378
Fusion event
HIV-CENPK integration
Validated
No
Detection method
NG-SGS
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30024859
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr5
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
64848090/65552263 (Hg38)
End
64848090/65552263 (Hg38)
Orient
-
Location type
Intronic
Target gene
CENPK
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-450b-5p ; hsa-mir-4528 ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-6759-3p ; hsa-mir-6734-3p ; hsa-mir-3646 ; hsa-mir-1252-3p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-106a-3p ; hsa-mir-885-3p ; hsa-mir-5589-3p ; hsa-mir-95-5p ; hsa-mir-3662
Nearest miRNA
hsa-mir-10397/Upstream/5848560; hsa-mir-103a-1/Downstream/6617204;
Nearest TSS
ENST00000502646/Upstream/1028; ENST00000508982/Downstream/2702;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/448874, chr5-CpG: 43/Downstream/10685
Upstream sequence
taggccaggctggtctTTGTTCTAATTTTAACAAGGCAGCGTAATAGCAACTAACAAGCAATTTACTCAGTTGTTAAATATATGTATAGTTGCTAAAAGA
Downstream sequence
CAAATAATAAAGAAAATACTCTCTTATTTATAATAGCTTGTTCTAGAAAGTTTTTAGAATATTCTTTCAATTCTTAAAGCAGGAAGAGTAAGAAGTTTTC
Reference
Sharaf, R., et al.HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers. J Clin Invest,2018,128(9): 4074-4085.
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