Basic Information
VIS ID
TVIS30000396
Fusion event
HIV-SPEN integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26912621
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr1
Cytoband
p36.13
Reference genome
GRCh37/hg19
Start
16230028/15903533 (Hg38)
End
16230028/15903533 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
SPEN
miRNAs that regulate target gene
hsa-mir-151a-5p ; hsa-mir-877-3p ; hsa-mir-23b-5p ; hsa-mir-769-5p ; hsa-mir-615-3p ; hsa-mir-193b-3p ; hsa-mir-423-3p ; hsa-mir-324-5p ; hsa-mir-331-3p ; hsa-mir-328-3p ; hsa-mir-106b-5p ; hsa-mir-320a ; hsa-mir-186-5p ; hsa-mir-125b-5p ; hsa-mir-196a-5p ; hsa-mir-92a-3p ; hsa-mir-16-5p ; hsa-mir-18a-5p ; hsa-mir-18b-5p ; hsa-mir-214-3p ; hsa-mir-3619-5p ; hsa-mir-4722-5p ; hsa-mir-4735-3p ; hsa-mir-4768-3p ; hsa-mir-6165 ; hsa-mir-761 ; hsa-mir-885-3p
Nearest miRNA
hsa-mir-12136/Upstream/3324510; hsa-mir-101-1/Downstream/955416;
Nearest TSS
ENST00000473358/Upstream/26957; ENST00000487496/Downstream/35050;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/53911, chr1-CpG: 22/Downstream/30842
Upstream sequence
gctggagtgcagtggcaccatcacacctcactacgcctcaacctcctgggcttagataatcctcccaccttagactcctagggagctgggaccacaggcg
Downstream sequence
catgccaccatgcctaattttttgtagagatggggttttgtcctgttgcgcaggctggtctcaaactcctgggctcaagtgatctgcctgccttggcctc
Reference
Sunshine, S., et al. HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay. J Virol,2016, 90(9): 4511-4519.
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