Basic Information
VIS ID
TVIS30000428
Fusion event
HIV-ZC3H6 integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26912621
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr2
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
113074525/112316948 (Hg38)
End
113074525/112316948 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2B
Target gene
ZC3H6
miRNAs that regulate target gene
hsa-mir-6516-5p ; hsa-mir-1273e ; hsa-mir-455-3p ; hsa-mir-6499-3p ; hsa-mir-4722-5p ; hsa-mir-2467-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-1827 ; hsa-mir-219b-3p ; hsa-mir-4768-3p ; hsa-mir-4649-3p ; hsa-mir-4257 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-1912 ; hsa-mir-1295b-5p ; hsa-mir-6806-5p ; hsa-mir-330-3p ; hsa-mir-3142 ; hsa-mir-1245b-5p ; hsa-mir-6871-3p ; hsa-mir-1183 ; hsa-mir-6835-3p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-5580-3p ; hsa-mir-4789-3p ; hsa-mir-8485
Nearest miRNA
hsa-mir-1285-2/Upstream/545814; hsa-mir-10b/Downstream/1266011;
Nearest TSS
ENST00000437798/Upstream/17092; ENST00000502881/Downstream/15194;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/40568, chr2-CpG: 129/Downstream/115590
Upstream sequence
ttaaatgatttaatcctacagtgaccctacaaagtagttaatgttattatccccattttattcatggcaccaagaggttaagtaagttcccatggtagct
Downstream sequence
cagcaagaaatggtgagtgctggttgccaattcaggcagtATCCTGTGAGGTCTTGCTCACTGTGCTGCCTTAATGCATGTAGCTACATCCACTGTCTTG
Reference
Sunshine, S., et al. HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay. J Virol,2016, 90(9): 4511-4519.
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