Basic Information
VIS ID
TVIS30000468
Fusion event
HIV-TERT integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26912621
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
1279242/1279127 (Hg38)
End
1279242/1279127 (Hg38)
Orient
+
Location type
Intronic
Target gene
TERT
miRNAs that regulate target gene
hsa-mir-138-5p ; hsa-mir-498 ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-512-5p ; hsa-mir-1207-5p ; hsa-mir-1266-5p ; hsa-mir-1182 ; hsa-mir-181a-5p ; hsa-mir-6776-3p ; hsa-mir-197-3p ; hsa-mir-6740-3p ; hsa-mir-6760-3p ; hsa-mir-532-5p ; hsa-mir-3064-5p ; hsa-mir-422a ; hsa-mir-346 ; hsa-mir-1226-3p ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-143-3p ; hsa-mir-3161 ; hsa-mir-3605-5p ; hsa-mir-3620-3p ; hsa-mir-3682-3p ; hsa-mir-4323 ; hsa-mir-4712-3p ; hsa-mir-4733-3p ; hsa-mir-4758-3p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-7112-3p
Nearest miRNA
hsa-mir-4635/Upstream/216153; hsa-mir-10397/Downstream/30183;
Nearest TSS
ENST00000502646/Upstream/12603; ENST00000605200/Downstream/3883;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1529, chr5-CpG: 37/Downstream/3407
Nearest cancer related gene
TERT(OG, No orient, 0)
Upstream sequence
CTTCTCTGACGGAAACTGGAATCCAGTGGGACCCTCCTTGGGAATAGGAGCCCGGGCAGTCAGGGTGCACAGTCGGCCCCATGTGCTGCAGGAAAGGCTG
Downstream sequence
AAGGCCTCCACCCTAGGTGCCAGGTGTGTCCTCAACAGTGACAGGGTCACCTGCACTCCCTGCGGCCCACCCAGGAGTACCTCCTCCACCCAACATGAGG
Reference
Sunshine, S., et al. HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay. J Virol,2016, 90(9): 4511-4519.
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