Basic Information
VIS ID
TVIS30000523
Fusion event
HIV-CHUK integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26912621
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr10
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
101965515/100205758 (Hg38)
End
101965515/100205758 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
CHUK
miRNAs that regulate target gene
hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-223-3p ; hsa-mir-23b-3p ; hsa-mir-195-5p ; hsa-mir-98-5p ; hsa-mir-23a-3p
Nearest miRNA
hsa-mir-107/Upstream/1281190; hsa-mir-1307/Downstream/769227;
Nearest TSS
ENST00000439456/Upstream/9816; ENST00000444359/Downstream/23861;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/19608, chr10-CpG: 43/Downstream/23612
Nearest cancer related gene
CHUK(TSG, No orient, 0)
Upstream sequence
ggctcacgcctgtaatcccagcactttgggaagccaaggcgggcagatcccttgaggtcaggagttcaagagcagcctggccaacacggtgaaaccctgt
Downstream sequence
ctctactaaaaatgcaaaaattagctgggcgtggtggtgtgcacctataatcccagctactcgggagactgagacaggagaatcgcttgtacccgggagg
Reference
Sunshine, S., et al. HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay. J Virol,2016, 90(9): 4511-4519.
Curate