Basic Information
VIS ID
TVIS30000529
Fusion event
HIV-GTF2H1 integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26912621
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
18374835/18353288 (Hg38)
End
18374835/18353288 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
GTF2H1
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-132-3p ; hsa-mir-1-3p ; hsa-mir-30a-5p ; hsa-mir-100-5p ; hsa-mir-99a-5p ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-493-5p ; hsa-mir-6867-5p ; hsa-mir-190a-3p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-5580-3p ; hsa-mir-450b-5p ; hsa-mir-891b ; hsa-mir-466 ; hsa-mir-4789-3p ; hsa-mir-4643 ; hsa-mir-129-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-4325 ; hsa-mir-7703
Nearest miRNA
hsa-mir-210/Upstream/2383667; hsa-let-7a-2/Downstream/34499;
Nearest TSS
ENST00000527297/Upstream/1190; ENST00000469976/Downstream/41100;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/30371, chr11-CpG: 73/Downstream/41087
Upstream sequence
cactccagcctgggcgacaagagcgaagctccatctcaaaTAGATAGataaatatttaaatatttaaaaataaaaacatgtattttatcactgcggcttg
Downstream sequence
aaaaccttcactgcctcccttcactgcagtagtctgagtgcctttgtctggcctgcaaaactctttatagtctggccccagcccactactcgagtctcat
Reference
Sunshine, S., et al. HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay. J Virol,2016, 90(9): 4511-4519.
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