Basic Information
VIS ID
TVIS30000536
Fusion event
HIV-EMSY integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26912621
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr11
Cytoband
q13.5
Reference genome
GRCh37/hg19
Start
76190375/76479331 (Hg38)
End
76190375/76479331 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
EMSY
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-31-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-657 ; hsa-mir-329-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-20b-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-17-5p ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181a-5p ; hsa-mir-181b-5p
Nearest miRNA
hsa-mir-10392/Upstream/1144145; hsa-let-7a-2/Downstream/2922691;
Nearest TSS
ENST00000527297/Upstream/32392; ENST00000531998/Downstream/34066;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/33548, chr11-CpG: 92/Downstream/191074
Nearest cancer related gene
EMSY(OG, No orient, 0)
Upstream sequence
agtgccagctgatgccacaagtggacaattccacacctgacttcatgtggtaaattgtaattaaaacacaggtgcacaccacacagtttattcagcgttc
Downstream sequence
ccaagggaaaaaagactccttctgccttctgtagcagtgatatatcttttccttgtacacccagattcccctcacacaagcacttccacagagggtaata
Reference
Sunshine, S., et al. HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay. J Virol,2016, 90(9): 4511-4519.
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