Basic Information
VIS ID
TVIS30000561
Fusion event
HIV-SOS2 integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26912621
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr14
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
50671220/50204502 (Hg38)
End
50671220/50204502 (Hg38)
Orient
+
Location type
Intronic
Target gene
SOS2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-1-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-4276 ; hsa-mir-513b-5p ; hsa-mir-6832-3p ; hsa-mir-6866-3p ; hsa-mir-4719 ; hsa-mir-6835-3p ; hsa-mir-188-5p ; hsa-mir-548e-5p ; hsa-mir-152-3p ; hsa-mir-148b-3p ; hsa-mir-148a-3p
Nearest miRNA
hsa-mir-208a/Upstream/237991; hsa-mir-1185-1/Downstream/95353;
Nearest TSS
ENST00000550708/Upstream/23848; ENST00000426751/Downstream/26599;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/87716, chr14-CpG: 114/Downstream/26580
Upstream sequence
CCTGAACCTTTAAAAAAAAGTTATCAGTTAAAGTAATGGCAAAATAATATAAATTGAACAAAAGTCAAAGAGAATCTTATATATAATATTTTACTATAAT
Downstream sequence
GGTTACTCAAAACAGACATAAAACACAAAATGAAGAAAAAAACTATTTGTTGGTCTCTGTAAACTTTTCTTAACCCACAGAGcagtggttcttaagcatt
Reference
Sunshine, S., et al. HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay. J Virol,2016, 90(9): 4511-4519.
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