Basic Information
VIS ID
TVIS30000565
Fusion event
HIV-TRAF3 integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26912621
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr14
Cytoband
q32.32
Reference genome
GRCh37/hg19
Start
103297202/102830865 (Hg38)
End
103297202/102830865 (Hg38)
Orient
+
Location type
Intronic
Target gene
TRAF3
miRNAs that regulate target gene
hsa-mir-32-5p ; hsa-mir-26b-5p ; hsa-mir-3191-3p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4707-3p ; hsa-mir-6746-5p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-129-5p ; hsa-mir-6867-5p ; hsa-mir-4694-5p ; hsa-mir-4286 ; hsa-mir-662 ; hsa-mir-3178 ; hsa-mir-34a-5p ; hsa-mir-361-3p ; hsa-mir-3679-3p ; hsa-mir-4639-3p ; hsa-mir-548e-5p ; hsa-mir-6777-3p ; hsa-mir-6805-5p ; hsa-mir-6846-5p ; hsa-mir-6848-5p
Nearest miRNA
hsa-mir-1185-1/Upstream/291139; hsa-mir-12121/Downstream/1286540;
Nearest TSS
ENST00000550708/Upstream/511; ENST00000558880/Downstream/41062;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/52497, chr14-CpG: 27/Downstream/76635
Upstream sequence
TCTGCCAGGCTGTGGTATTCTGTGTTCTTACAGAGAAGCTGCAGTGCCCAGCAGTTACCCAGGGGTGAATCTGAATCACCACCTGTTAAATCAAGGTCAT
Downstream sequence
GATACTGTATTTACTAAGGCAGGACAACATAGTAATTTAGGCTCAACTTACAAGTTGCAACTTATTACAAGTAATAAGAGGTTCGGCTTACAAGGTTTGA
Reference
Sunshine, S., et al. HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay. J Virol,2016, 90(9): 4511-4519.
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