Basic Information
VIS ID
TVIS30000618
Fusion event
HIV-DOK6 integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26912621
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr18
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
67224850/69557614 (Hg38)
End
67224850/69557614 (Hg38)
Orient
-
Location type
Intronic
Target gene
DOK6
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1-3p ; hsa-mir-6818-5p ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-8485 ; hsa-mir-4732-5p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-599 ; hsa-mir-578 ; hsa-mir-3679-3p ; hsa-mir-653-5p ; hsa-mir-3161 ; hsa-mir-2355-5p ; hsa-mir-6793-3p ; hsa-mir-642a-5p ; hsa-mir-141-5p ; hsa-mir-5011-5p ; hsa-mir-410-3p
Nearest miRNA
hsa-mir-1-2/Upstream/2475928; hsa-mir-548av/Downstream/3295707;
Nearest TSS
ENST00000575820/Upstream/156559; ENST00000582172/Downstream/61080;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/87602, chr18-CpG: 80/Downstream/647671
Upstream sequence
AATGGTTTTCATCAGATGGAAGGGGATTAAGAAGGTATTTAATGATGGCATGCTGGCTGGCTGGTTAACACAGTGGAAAGCTGAGGGTGTGAACCAGCTG
Downstream sequence
TGATCCTGGGAATTCCTGGAGTCCTAGCAACAACATGGAATTTTCTATATGGGAATCGGAGGGGCACCTAGGAGCCTGTTTGATGAAATAACTGGCATGT
Reference
Sunshine, S., et al. HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay. J Virol,2016, 90(9): 4511-4519.
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