Basic Information
VIS ID
TVIS30000620
Fusion event
HIV-UHRF1 integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26912621
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
4947670/4947658 (Hg38)
End
4947670/4947658 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
UHRF1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-let-7b-5p ; hsa-mir-124-3p ; hsa-mir-146a-5p ; hsa-mir-34a-5p ; hsa-mir-7-5p ; hsa-mir-615-3p ; hsa-mir-191-5p ; hsa-mir-221-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-let-7a-5p ; hsa-mir-146b-5p ; hsa-mir-9-5p
Nearest miRNA
hsa-mir-1227/Upstream/14918; hsa-let-7e/Downstream/1441980;
Nearest TSS
ENST00000633603/Upstream/37283; ENST00000588337/Downstream/21455;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3172, chr19-CpG: 20/Downstream/3000
Nearest cancer related gene
UHRF1(OG, No orient, 0)
Upstream sequence
ggtgcactctctgctcactgcaacctctgcctcctgggctcaagcgattctcatgcctcagcctcctgagtagctgggattacaggtgcttgccacctcg
Downstream sequence
cctggctaatttttgtatttttagtagagatggggttttgccatgttggccaggctggtctcgaactcctgacctcaggtgatcttccctcctcggcctc
Reference
Sunshine, S., et al. HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay. J Virol,2016, 90(9): 4511-4519.
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