Basic Information
VIS ID
TVIS30000639
Fusion event
HIV-DYRK1A integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26912621
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr21
Cytoband
q22.13
Reference genome
GRCh37/hg19
Start
38801454/37429152 (Hg38)
End
38801454/37429152 (Hg38)
Orient
+
Location type
Intronic
Target gene
DYRK1A
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-148a-3p ; hsa-mir-192-5p ; hsa-mir-324-5p ; hsa-mir-99b-5p ; hsa-mir-92a-3p ; hsa-mir-1246 ; hsa-mir-224-3p ; hsa-mir-522-3p ; hsa-mir-620 ; hsa-mir-2113 ; hsa-mir-298 ; hsa-mir-1270 ; hsa-mir-5680 ; hsa-mir-6880-5p ; hsa-mir-26a-5p ; hsa-mir-26b-5p ; hsa-mir-455-5p ; hsa-mir-2682-3p ; hsa-mir-6781-3p ; hsa-mir-6844 ; hsa-mir-3944-5p ; hsa-mir-143-5p ; hsa-mir-3165 ; hsa-mir-8071 ; hsa-mir-4683 ; hsa-mir-3152-5p ; hsa-mir-6836-3p ; hsa-mir-5692a ; hsa-mir-335-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-550b-2-5p ; hsa-mir-3157-5p ; hsa-mir-550a-5p ; hsa-mir-550a-3-5p ; hsa-mir-1271-3p ; hsa-mir-3135a ; hsa-mir-4716-5p ; hsa-mir-5685 ; hsa-mir-4690-3p ; hsa-mir-7151-5p
Nearest miRNA
hsa-let-7c/Upstream/1708344; hsa-mir-3197/Downstream/2017858;
Nearest TSS
ENST00000624081/Upstream/8777; ENST00000462274/Downstream/43628;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/61227, chr21-CpG: 72/Downstream/134400
Upstream sequence
ATCCATATTGCTAATGGATATACATTAGAGAGAAACACAAATAAGTTAATTTTAATTTTTATAAACCATCCACAAAATATACTCCATGGAATCAGATACT
Downstream sequence
CAAAAAGATACCGAGATGTAAATATTTATGTTGTTAACGCAAATCCAGGTCTGCTTTGTAGAAGGTTACCAAAGCTTAAAAACCATTGTTGAGTGCTTGC
Reference
Sunshine, S., et al. HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay. J Virol,2016, 90(9): 4511-4519.
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