Basic Information
VIS ID
TVIS30000696
Fusion event
HIV-ITK integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26912621
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr5
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
156631249/157204238 (Hg38)
End
156631249/157204238 (Hg38)
Orient
-
Location type
Intronic
Target gene
ITK
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-6083 ; hsa-mir-7111-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-5196-3p ; hsa-mir-3183 ; hsa-mir-3074-3p ; hsa-mir-3591-3p ; hsa-mir-21-3p
Nearest miRNA
hsa-mir-10397/Upstream/2374698; hsa-mir-103a-1/Downstream/3270164;
Nearest TSS
ENST00000502646/Upstream/23371; ENST00000519759/Downstream/18511;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/61182, chr5-CpG: 91/Downstream/61564
Nearest cancer related gene
ITK(OG, No orient, 0)
Upstream sequence
tagctgggactacaggtgcacaccatgaggcttggctaatttatgtaattttttgcattgtctcactatgttgcccaggctgctctcgaattcttgggct
Downstream sequence
caaatgacctcctacctcagcctctcaaagatctgggattggctgggcatgttggctcatgcctgtaatcccagcactttgggaggctgaggcgggcaga
Reference
Sunshine, S., et al. HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay. J Virol,2016, 90(9): 4511-4519.
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