Basic Information
VIS ID
TVIS30000701
Fusion event
HIV-PHIP integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26912621
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
79777675/79067958 (Hg38)
End
79777675/79067958 (Hg38)
Orient
-
Location type
Intronic
Target gene
PHIP
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-760 ; hsa-mir-5011-5p ; hsa-mir-218-5p ; hsa-mir-3163 ; hsa-mir-548e-5p ; hsa-mir-545-3p ; hsa-mir-6083 ; hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-190a-3p ; hsa-mir-4795-5p ; hsa-mir-4729 ; hsa-mir-6074 ; hsa-mir-1277-5p ; hsa-mir-186-5p ; hsa-mir-3133 ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-664a-3p ; hsa-mir-3924 ; hsa-mir-105-5p ; hsa-mir-33a-3p ; hsa-mir-4307 ; hsa-mir-4524b-3p ; hsa-mir-7853-5p ; hsa-mir-129-5p ; hsa-mir-3680-3p ; hsa-mir-450b-5p ; hsa-mir-4762-5p ; hsa-mir-507 ; hsa-mir-518a-5p ; hsa-mir-527 ; hsa-mir-548aw ; hsa-mir-551b-5p ; hsa-mir-557
Nearest miRNA
hsa-mir-10398/Upstream/528649; hsa-mir-1202/Downstream/11244784;
Nearest TSS
ENST00000381078/Upstream/85015; ENST00000604516/Downstream/10278;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/156958, chr6-CpG: 131/Downstream/9137
Upstream sequence
TTTGAACAAAAGGGTCATCTTCTGAGAATGTGAATTACAGTATGGAAGAAACAAGAAACTGAGCTCTTTGAGAGGTTTATTATCCCGCATTTTTGGCTAA
Downstream sequence
AACAACATTTTCTGATAGTATGCTACTTCACATAAACAGCCATCCTTCCCAGCCAAAAAATTTTGCCATTATCTCAGTGGAAGGTATTGTTAAAAGGCAA
Reference
Sunshine, S., et al. HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay. J Virol,2016, 90(9): 4511-4519.
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