Basic Information
VIS ID
TVIS30000749
Fusion event
HIV-MPHOSPH9 integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26912621
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
123680890/123196343 (Hg38)
End
123680890/123196343 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
MPHOSPH9
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-340-5p ; hsa-mir-130b-3p ; hsa-mir-19b-3p ; hsa-mir-15b-5p ; hsa-mir-3126-3p ; hsa-mir-3128 ; hsa-mir-4720-5p ; hsa-mir-4799-3p ; hsa-mir-5088-5p ; hsa-mir-515-5p ; hsa-mir-519d-5p ; hsa-mir-519e-5p ; hsa-mir-5588-5p ; hsa-mir-564 ; hsa-mir-5695 ; hsa-mir-6868-5p
Nearest miRNA
hsa-let-7i/Upstream/185615; hsa-mir-3612/Downstream/168421;
Nearest TSS
ENST00000382841/Upstream/16363; ENST00000536130/Downstream/6495;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/44714, chr12-CpG: 94/Downstream/36477
Upstream sequence
ggaggctgaggcaggagaatcccttgaaccagggagatggaggttgcagtgagccaagatcgcaccattgcactccagcctgggcaacaagggcgagact
Downstream sequence
ccatctcaacaaaaaaacaaaaTAGACAGTTTCCACCAAAATTTTGTTCATAAGGCCATATGTATCTCATACATATACACACTACTCTATGATAGCTATC
Reference
Sunshine, S., et al. HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay. J Virol,2016, 90(9): 4511-4519.
Curate