Basic Information
VIS ID
TVIS30000755
Fusion event
HIV-TBC1D4 integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26912621
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr13
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
75897721/75323585 (Hg38)
End
75897721/75323585 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13E
Target gene
TBC1D4
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-30a-5p ; hsa-mir-19b-3p ; hsa-mir-29b-2-5p ; hsa-mir-7150 ; hsa-mir-4736 ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-1193 ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-8069 ; hsa-mir-4456 ; hsa-mir-4494 ; hsa-mir-4463
Nearest miRNA
hsa-mir-1297/Upstream/9105261; hsa-mir-1267/Downstream/2374427;
Nearest TSS
ENST00000623511/Upstream/7033; ENST00000471792/Downstream/2665;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1187904, chr13-CpG: 197/Downstream/157131
Upstream sequence
ttttaattttttttaaaaaaaGCAATTCTCCAAAAATCACTACGTCTAATTTTGTGTTACTAAAAGAACAAGAATAAGATTTAACAGGCTATACATTTTC
Downstream sequence
CATACTGGGGATAAAAACAAAACAAAATAGAATGTTCACAAGATTCAAGAGGTCGTTCACAAGATTCAAGAGGTCCTTCACAGATCCCTCATGCTATCTA
Reference
Sunshine, S., et al. HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay. J Virol,2016, 90(9): 4511-4519.
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