VISDB - VIS Detail

Basic Information

VIS ID

TVIS30000786

Fusion event

HIV-P4HB integration

Validated

Detection method

QiaQuick PCR and Sequencing

Data source

download(RID)

Sample type

Cell line

Disease

HIV-infected disease (HID)

Quality evaluation

Normal

Reported year

2016

PubMed ID

26912621

Virus Sequence

Virus name

HIV

Reference genome

K03455.1

Host Sequence

Chromosome

chr17

Cytoband

q25.3

Reference genome

GRCh37/hg19

Start

79814616/81856740 (Hg38)

End

79814616/81856740 (Hg38)

Orient

Location type

Intronic

Target gene

P4HB

miRNAs that regulate target gene

hsa-mir-210-3p ; hsa-mir-615-3p ; hsa-mir-18a-3p ; hsa-mir-484 ; hsa-mir-183-5p ; hsa-mir-92a-3p ; hsa-mir-188-5p ; hsa-mir-3672 ; hsa-mir-4520-3p ; hsa-mir-6516-3p ; hsa-mir-422a ; hsa-mir-378i ; hsa-mir-378h ; hsa-mir-378f ; hsa-mir-378e ; hsa-mir-378d ; hsa-mir-378c ; hsa-mir-378b ; hsa-mir-378a-3p ; hsa-mir-4638-3p ; hsa-mir-518c-5p ; hsa-mir-451b ; hsa-mir-514a-5p ; hsa-mir-548n ; hsa-mir-1252-5p ; hsa-mir-1294 ; hsa-mir-135b-3p ; hsa-mir-298 ; hsa-mir-3650 ; hsa-mir-3919 ; hsa-mir-4292 ; hsa-mir-4308 ; hsa-mir-4710 ; hsa-mir-4756-3p ; hsa-mir-4787-5p ; hsa-mir-483-5p ; hsa-mir-548e-5p ; hsa-mir-597-5p ; hsa-mir-6077 ; hsa-mir-6134 ; hsa-mir-642b-5p ; hsa-mir-668-3p ; hsa-mir-670-5p ; hsa-mir-6752-5p ; hsa-mir-6758-5p ; hsa-mir-6782-5p ; hsa-mir-6791-5p ; hsa-mir-6842-5p ; hsa-mir-6856-5p ; hsa-mir-7110-5p ; hsa-mir-7854-3p ; hsa-mir-887-3p

Nearest miRNA

hsa-mir-10226/Upstream/162871; hsa-mir-4525/Downstream/379928;

Nearest TSS

ENST00000595228/Upstream/730; ENST00000576021/Downstream/2429;

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/10128, chr17-CpG: 147/Downstream/3253

Upstream sequence

tttcttcttttttttttttttttttgagacggaatctacctctgtcgtccaggctggagaatgcagtggcgccatcctggctcactgcaacctccatctc

Downstream sequence

ccaggttcaagtgattctcctgcctcggcctcccaaatagctggtattacaggcgcccgccaccatgcccagctaatttttgtatttttagtagagacgg

Reference

Sunshine, S., et al. HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay. J Virol,2016, 90(9): 4511-4519.