Basic Information
VIS ID
TVIS30000904
Fusion event
HIV-ARID3B integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
74866089/74573748 (Hg38)
End
74866641/74573748 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARID3B
miRNAs that regulate target gene
hsa-mir-125a-5p ; hsa-mir-125b-5p ; hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-181d-5p ; hsa-let-7f-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-let-7e-5p ; hsa-mir-98-5p ; hsa-let-7g-5p ; hsa-let-7i-5p ; hsa-mir-543 ; hsa-mir-3611 ; hsa-mir-3927-3p ; hsa-mir-4451 ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-mir-4709-3p ; hsa-mir-6831-5p ; hsa-mir-6818-5p ; hsa-mir-203a-3p ; hsa-mir-147a ; hsa-mir-593-5p ; hsa-mir-6804-3p ; hsa-mir-5580-5p ; hsa-mir-3692-5p ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-6891-3p ; hsa-mir-6072
Nearest miRNA
hsa-mir-10393/Upstream/162316; hsa-mir-11181/Downstream/214924;
Nearest TSS
ENST00000557528/Upstream/29398; ENST00000566468/Downstream/17439;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/32128, chr15-CpG: 162/Downstream/40849
Target sequence
GAGGGTGACGAAGGTGGAGCCACACAGGTTGCTGAAGGCCTTCTCCTAGAGAGGCTGGGGTGCTGGCCATGTGTTCTGAGGGCTGACCTGGCTGGTGAACCCATTGCTATGACTGAATACAAAGCCAGGAAGTTGAGTCACTCAGCTCTAAACTCAGTCACACCATAGTCTACAGTGAAGATGGCTCTTGGGGATGTGCAGAGTGAGGAGAGAAGGAAAGAGAATTGGGAGGGTGCATTATAAAGCAGATGCCGG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate