Basic Information
VIS ID
TVIS30000907
Fusion event
HIV-BRWD3 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
80026080/80770581 (Hg38)
End
80027069/80770581 (Hg38)
Orient
+
Location type
Intronic
Target gene
BRWD3
miRNAs that regulate target gene
hsa-mir-378a-3p ; hsa-mir-5010-3p ; hsa-mir-548at-5p ; hsa-mir-651-5p ; hsa-mir-548aw ; hsa-mir-4795-3p ; hsa-mir-556-3p ; hsa-mir-223-5p ; hsa-mir-6882-3p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-509-3p ; hsa-mir-126-5p ; hsa-mir-3159 ; hsa-mir-22-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-377-3p ; hsa-mir-216b-3p ; hsa-mir-4704-5p ; hsa-mir-297 ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-4711-3p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-8068
Nearest miRNA
hsa-let-7f-2/Upstream/1869332; hsa-mir-105-1/Downstream/3455171;
Nearest TSS
ENST00000429181/Upstream/36436; ENST00000474113/Downstream/39102;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/195541, chrX-CpG: 21/Downstream/38843
Target sequence
GGTACTGATCGAACGTATTTCAAAACAATACAAGCTACTTATGACAAATCCACAGCCAATATCATACTGAATGGGCAAAAACTGGAGGCACTCCCTTTGAAAACTGGGACAAGACAGGGATGCCCTCTCTCACCACTCCTATTCACCATAGTGTTGGAAGTTCTGGCCAGGGCAATCAGGCAAGAGAAAGAAATAAAGGGTATTCGATTAGGAAAAGAGGAAGTCAAATTGTCCCTGTCTGCAGATGACATGACT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate