Basic Information
VIS ID
TVIS30000909
Fusion event
HIV-EEF1D integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
144675370/143593200 (Hg38)
End
144675876/143593200 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
EEF1D
miRNAs that regulate target gene
hsa-mir-93-3p ; hsa-mir-186-5p ; hsa-mir-149-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1204/Upstream/1416782; hsa-mir-10400/Downstream/139883;
Nearest TSS
ENST00000518652/Upstream/307; ENST00000504548/Downstream/2929;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/14735, chr8-CpG: 16/Downstream/618
Nearest cancer related gene
EEF1D(OG, No orient, 0)
Target sequence
GGAGCCACCGTCAAGACAGGGCTGGCACCCAAGGGCCCCAGCACAAGCTACAAAGGCCTCCCAGACTGACTCTCCCACAATGTGCACACAAGGACAGGACCTCCACCCAGTTCACTCCTCGGCTGGAGACACTAGGTGTCCTGCCCCTAATCTCACCAGAGCCACCTCATAAACCCTGCAAGCTCTGCGAAGGGCAGCTGGGCACAGCTGAAAGCCCAGCCACCAGCCCATGTCCTGGGTGGGACTGGGCAGGAG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate