Basic Information
VIS ID
TVIS30000910
Fusion event
HIV-GAB3 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q28
Reference genome
GRCh37/hg19
Start
153965955/154737680 (Hg38)
End
153966130/154737680 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRAXE ; FRAXF
Target gene
GAB3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p
Nearest miRNA
hsa-let-7f-2/Upstream/287294; hsa-mir-1184-1/Downstream/30916;
Nearest TSS
ENST00000429181/Upstream/41588; ENST00000475423/Downstream/13377;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/93562, chrX-CpG: 103/Downstream/12883
Target sequence
ATAGTCAGTGTCCAGAAAGATGTGGCGTAAAAAATCAATTACAGGCCAGGCGCAGTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGAGGATGACCTGAGGTCAGGAGTTCGAGCCTGGGCAACATGGTGAAGCCCCGTCTCTACTAAAAATACAAAAATTAGCCGGGCATGGT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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