Basic Information
VIS ID
TVIS30000913
Fusion event
HIV-HIST1H2AC integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
26131705/26131477 (Hg38)
End
26132092/26131477 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6C
Target gene
HIST1H2AC
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-98-5p ; hsa-mir-629-5p ; hsa-mir-504-5p ; hsa-mir-330-3p ; hsa-mir-221-3p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-3691/Upstream/7559597; hsa-mir-10398/Downstream/1016149;
Nearest TSS
ENST00000381078/Upstream/7274; ENST00000304218/Downstream/24877;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/6923, chr6-CpG: 56/Downstream/24744
Target sequence
GAACCTGGGAGGTGGAGATTGCAGTGAGCTGAGATCACACCATTGCCCTACAGCCTGGGTGACAGTGAGACTGCCTCAAGAAAAAACAAAAAAGAGTCAGCCCTAGAGATCTTGTAAGTTGCCTTTGGTGGGTCAGTCTTTCCTTTTCTTAAAGAATAGTACACATTGACAGCCAGGTAGCTCTATGATCCTGTTCTATAGAATTCAAAAAGTCGACAACCTTCCTTTGTTCCTTTCTGTTTTCTCTGCCTACGT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate