Basic Information
VIS ID
TVIS30000922
Fusion event
HIV-MOB1A integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
74383748/74156621 (Hg38)
End
74383983/74156621 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
MOB1A
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-181a-5p ; hsa-let-7b-5p ; hsa-mir-93-5p ; hsa-mir-513a-3p ; hsa-mir-513c-3p ; hsa-mir-3606-3p ; hsa-mir-4439 ; hsa-mir-3136-5p ; hsa-mir-548v ; hsa-mir-6857-3p ; hsa-mir-6855-3p ; hsa-mir-4513 ; hsa-mir-6507-5p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-186-5p ; hsa-mir-5197-3p ; hsa-mir-3682-5p ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-6514-3p ; hsa-mir-1295a ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-564 ; hsa-mir-6847-3p ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-1295b-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/3903616; hsa-mir-10b/Downstream/934191;
Nearest TSS
ENST00000437798/Upstream/8576; ENST00000488086/Downstream/21693;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/8491, chr2-CpG: 84/Downstream/21604
Nearest cancer related gene
MOB1A(TSG, No orient, 0)
Target sequence
ACGCCTATCAATCAGATTAAACTCCTAAAAAGAGAAGAAAAATAACAATTAAAAATGGATCTAAAACTGAAACTCTGTAAATGTCTTTTGGAGAAGGGATTCCCAACTCTAGTTTTCTGAAGTCCAAAAGAATGATGAAATAACCTCTGTGAACATTTTAAAATAGGCATTTATTCTTTTTCTTTTTTTTTTCTTTTTTGTACAGATGTGGTCTATGTTGCCAAGGCTGGTACTG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate