Basic Information
VIS ID
TVIS30000924
Fusion event
HIV-NEAT1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
65200157/65432686 (Hg38)
End
65200357/65432686 (Hg38)
Orient
-
Location type
ncRNA_exonic
Fragile sites / regions
FRA11H
Target gene
NEAT1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-449b-5p
Nearest miRNA
hsa-mir-10392/Upstream/302708; hsa-let-7a-2/Downstream/11772;
Nearest TSS
ENST00000527297/Upstream/7135; ENST00000620902/Downstream/55450;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/9099, chr11-CpG: 26/Downstream/22333
Nearest cancer related gene
NEAT1(OG, No orient, 0)
Target sequence
AGAGTGACATAATGGACACTAGAGACTCAAAGTGGGGAGGGTAAGAGGGGGGCAAGGTATAAAAAACCACATATTGGGTACAATGTACACTACTCAGGTGACCGGTGCAGTAAAATCTCAGACTTCACTACTGTAGAATTCATCTATATGACCAAAAGCCATTTGTACCCCAAAAGCCATTGAAATTAAAAAAAAAAAAAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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