Basic Information
VIS ID
TVIS30000925
Fusion event
HIV-NR3C2 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.23
Reference genome
GRCh37/hg19
Start
149355459/148434307 (Hg38)
End
149356217/148434307 (Hg38)
Orient
+
Location type
Intronic
Target gene
NR3C2
miRNAs that regulate target gene
hsa-mir-19b-3p ; hsa-mir-135a-5p ; hsa-mir-124-3p ; hsa-mir-335-5p ; hsa-mir-148b-3p ; hsa-mir-944 ; hsa-mir-548i ; hsa-mir-301b-3p
Nearest miRNA
hsa-mir-12113/Upstream/651639; hsa-mir-1305/Downstream/4055020;
Nearest TSS
ENST00000502981/Upstream/65837; ENST00000504874/Downstream/2553;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/701540, chr4-CpG: 294/Downstream/7753
Target sequence
AAACCTCTTCCTTGTTTTTTCTAAATATATACAACATGCTATCTGCAACAAGGAAAGCCAAGAGATATTTTACAGTAAATAAAATATGTCTTCTTGCAGATCTGAAAAGTTATAAATATACCAATTCAAAACTGCAGTGACATATTTCACTTCCAATATAAGTAAGAAAGCAAGATTGTCCACTTAGTAATTTTAGATATGCTGAGTCTTTAAAAGCTCTCAACAGTTAAGGAAATGATTTATTTGTATTGAAAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate