Basic Information
VIS ID
TVIS30000928
Fusion event
HIV-PRKCH integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
61864877/61398159 (Hg38)
End
61865742/61398159 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
PRKCH
miRNAs that regulate target gene
hsa-mir-376c-3p ; hsa-mir-432-5p ; hsa-mir-376a-3p ; hsa-mir-493-3p ; hsa-mir-4531 ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-26a-2-3p ; hsa-mir-26a-1-3p ; hsa-mir-6731-3p ; hsa-mir-4254 ; hsa-mir-3690 ; hsa-mir-3938 ; hsa-mir-3675-3p ; hsa-mir-216b-5p ; hsa-mir-24-3p
Nearest miRNA
hsa-mir-208a/Upstream/749448; hsa-mir-1185-1/Downstream/2696865;
Nearest TSS
ENST00000550708/Upstream/7465; ENST00000557473/Downstream/44399;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/75410, chr14-CpG: 112/Downstream/296970
Target sequence
ACCACAATACCACAATCACACCTAAATAACATCAACAATTCTGTAATATCCTCACAGATCCAGGCACGGTTTCCATTTCTTCACTTGCCTCCTGGGAGTTAATGTTTCTTTTATAATTTGTGTTTGAATTGGGATAAAATGTGGCCCATATATTGCAAATGATTAATATGCCTCTCTCTTGTTACTTTGGTTCTCTTTCCTTTACTTTTTTCTTCCAATGTTTGGTAGAAGAAACCAAGTCTCTTTTCCTGTAAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate