Basic Information
VIS ID
TVIS30000929
Fusion event
HIV-PTGES3 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
57062296/56668512 (Hg38)
End
57062810/56668512 (Hg38)
Orient
+
Location type
Intronic
Target gene
PTGES3
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-mir-106b-5p ; hsa-mir-20a-5p ; hsa-mir-4709-5p ; hsa-mir-3668 ; hsa-mir-186-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/2331198; hsa-let-7i/Downstream/525992;
Nearest TSS
ENST00000382841/Upstream/22444; ENST00000556481/Downstream/19485;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/22473, chr12-CpG: 112/Downstream/18994
Target sequence
AGGATCACTTGAGCTCAGGAGTTCAAGACCTGCCTAAGCAACACAATGGCTTGCACAGCTAGGTAAATGGTGGCACCGATTTCTACAGGTAAGGAAAGTACAATTAAAAAATAATATGAATAGAACATCCTCCCTTCCTGTTGAAATCACCATGCCAGAGTCACGTGTGGAGAACTGTTAAATAAGCAGTTGCATAAAGCTGGAAACTTAGCTCCTTTTATTTAACTCTTAAGGTCTCAAAATACAAAATCTAGT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate