Basic Information
VIS ID
TVIS30000931
Fusion event
HIV-SKIV2L integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.33
Reference genome
GRCh37/hg19
Start
31929414/31961637 (Hg38)
End
31930302/31961637 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA6H
Target gene
SKIV2L
miRNAs that regulate target gene
hsa-mir-222-3p ; hsa-let-7e-5p
Nearest miRNA
hsa-mir-1236/Upstream/4697; hsa-mir-10398/Downstream/208393;
Nearest TSS
ENST00000381078/Upstream/140; ENST00000461915/Downstream/5191;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/2474, chr6-CpG: 74/Downstream/10316
Target sequence
GTGAGCAGCCCCACATCCCCGAATGTGTTTCGGAAGTCCCGGAACTTCTGGTTGCTCAGGGCCTTGATGGGCGAAGTGTAGATGGTGCTGGGAAGAGAGCATGAAGTTAGCCAGTCCCTCCGCAGACTCATGGCCCGCACTTCCTCTCCCACATGGAGCCCTCGTGGAAGCATGCCCCAGAAGCTCAGGTGCTCCTCTTCTTCACCCAAACTGCCCTTACATTCTCCTGCATGATATAACCCCAGAAAAATTCTG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate