Basic Information
VIS ID
TVIS30000936
Fusion event
HIV-SMG6 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
2164968/2261674 (Hg38)
End
2165900/2261674 (Hg38)
Orient
+
Location type
Intronic
Target gene
SMG6
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-331-3p ; hsa-mir-185-5p ; hsa-mir-93-5p
Nearest miRNA
hsa-mir-132/Upstream/211294; hsa-mir-10226/Downstream/431187;
Nearest TSS
ENST00000595228/Upstream/16762; ENST00000572709/Downstream/4457;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/202340, chr17-CpG: 100/Downstream/41549
Target sequence
GTGTATGCTATATCCCCAGTGTACGGATGTAAAGACAAGGAAAGAGATTAAAAAATCTGTTCATGCAAACAAAAAGAAATTTAGGAATGCAACCCATAAGATCTCACTCCTGGTCTGCAGTGACCACAAGTGACAGCTTCCTAGGAGCACGAAGGGCACTATTAGTGCCTTATTCAACCTTTTGACATATGTCACTTGCAAGTATTTCAAAAGCCATAGAGTTTTATAGATCTGTCCAGAAGTCTAAAGGAAAAC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate