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Viral Integration Site DataBase
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TVIS30000939
Basic Information
VIS ID
TVIS30000939
Fusion event
HIV-SRSF3 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
36568755/36600978 (Hg38)
End
36569057/36600978 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
SRSF3
miRNAs that regulate target gene
hsa-mir-361-5p
;
hsa-mir-186-5p
;
hsa-mir-124-3p
;
hsa-mir-374a-3p
;
hsa-mir-622
;
hsa-mir-877-5p
;
hsa-mir-6866-5p
;
hsa-mir-1303
;
hsa-mir-4795-3p
;
hsa-mir-6721-5p
;
hsa-mir-657
;
hsa-mir-7157-3p
;
hsa-mir-6737-3p
;
hsa-mir-5008-3p
;
hsa-mir-6860
;
hsa-mir-6889-3p
;
hsa-mir-612
;
hsa-mir-5189-5p
;
hsa-mir-3187-5p
;
hsa-mir-1285-3p
;
hsa-mir-5094
;
hsa-mir-5583-5p
;
hsa-mir-3129-3p
Nearest miRNA
hsa-mir-1236/Upstream/936189; hsa-mir-10398/Downstream/21458;
Nearest TSS
ENST00000381078/Upstream/575;
ENST00000462537/Downstream/74148;
Nearest CpG islands
None/Target,
chr6-CpG: 120/Upstream/6343
,
chr6-CpG: 42/Downstream/59831
Nearest cancer related gene
SRSF3
(OG, No orient, 0)
Target sequence
ATTCCCATTAACTAAGCCACCTGGAAAAGTTTAGGAATAGCAGAAACACTGCCATTTCTAAGAACGTAGCCTAAAAAGGTAGTCATTTACCTGCTCCGGCTGCGAGAGAAGCTTCTCCTTCTTGGAGATCTAAAAGCAGAAACAGGAAAATTAGGCTCATCATCAATTAGTATTTATGGCGTGAGGCATTTCCCAACTTTTCAATCTCACTGTTGGGCCCAGTGAATGTGCCGAAGAACTGGCACCCATCGTCCA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Sample Information
×
Sample name
B1
Sample type
PBMC
Gender
Female
CpG Island Information
×
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