VISDB - VIS Detail

Basic Information

VIS ID

TVIS30000945

Fusion event

HIV-TMEM106B integration

Validated

Yes

Detection method

QiaQuick PCR and Sequencing

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

25011556

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr7

Cytoband

p21.3

Reference genome

GRCh37/hg19

Start

12258834/12219208 (Hg38)

End

12259717/12219208 (Hg38)

Orient

Location type

Intronic

Target gene

TMEM106B

miRNAs that regulate target gene

hsa-mir-375 ; hsa-mir-877-5p ; hsa-mir-30b-5p ; hsa-mir-10a-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-651-3p ; hsa-mir-1252-5p ; hsa-mir-376c-3p ; hsa-mir-510-3p ; hsa-mir-4738-3p ; hsa-mir-5582-3p ; hsa-mir-6864-5p ; hsa-mir-6126 ; hsa-mir-526b-5p ; hsa-mir-6124 ; hsa-mir-5584-3p ; hsa-mir-4635 ; hsa-mir-148a-5p ; hsa-mir-6511a-5p ; hsa-mir-3714 ; hsa-mir-1910-3p ; hsa-mir-6807-5p ; hsa-mir-670-3p ; hsa-mir-4752 ; hsa-mir-6833-5p ; hsa-mir-3190-3p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-145-3p ; hsa-mir-4289 ; hsa-mir-4302 ; hsa-mir-7156-3p ; hsa-mir-6516-3p ; hsa-mir-1206 ; hsa-mir-1255b-5p ; hsa-mir-1255a ; hsa-mir-8084 ; hsa-mir-574-5p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-5011-5p ; hsa-mir-4279 ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-6789-3p ; hsa-mir-6778-3p ; hsa-mir-4707-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-1292-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-4532 ; hsa-mir-1247-3p ; hsa-mir-4258 ; hsa-mir-4740-3p ; hsa-mir-122-3p ; hsa-mir-4438 ; hsa-mir-6083

Nearest miRNA

hsa-mir-339/Upstream/5152163; hsa-mir-10399/Downstream/5908012;

Nearest TSS

ENST00000635602/Upstream/7885; ENST00000492762/Downstream/10540;

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/7620, chr7-CpG: 45/Downstream/184329

Target sequence

GTTTACAGGACAGGAGTTAGGAAGGAAGGAGAGAACAGATTGACATATTAGGGAGATCATCTCAAAACTGTGGAGATAAATATACATGGAGGCCATATTTTCAAATACTTTGTATATCAACAGAGGATGGAGCCCTTGAACAGTGAAGCTAGCAAAGCAACGCTGGCATATTCCATCACCGCAAATGAAACCTTTTCTTGAAAGTACAAAAGCTCTTTTCATTTAAACATGAGCACCCGGAAAGGATTGCAACAA

Reference

Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.