Basic Information
VIS ID
TVIS30000947
Fusion event
HIV-USO1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
76715640/75794487 (Hg38)
End
76716557/75794487 (Hg38)
Orient
-
Location type
Intronic
Target gene
USO1
miRNAs that regulate target gene
hsa-mir-197-3p ; hsa-mir-335-5p ; hsa-let-7b-5p ; hsa-mir-421
Nearest miRNA
hsa-mir-12113/Upstream/9517559; hsa-mir-1243/Downstream/779081;
Nearest TSS
ENST00000502981/Upstream/24364; ENST00000508454/Downstream/10522;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/69214, chr4-CpG: 133/Downstream/145449
Target sequence
GCTTTGCTATAAGAGGAAAATGCCTAAGCTTAATCAAGTGATACATACCCGTCTGTCGATCTTATCACCCTGCAAATTATACATTACAAATTATTCATACATATTACTACTTTAGAAAAGTCTAAATCTGGAAAAATCCCTCAAATACTTTTTCATAGTCTCTCTACAAACTCAAGCCAATAATTTGGGACAGGATGGTTCTAATGATACTTCTTTTATACAATAAAAAGTTAGAGGATACATTTAGAGGCTATA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate