Basic Information
VIS ID
TVIS30000957
Fusion event
HIV-chr6 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.33
Reference genome
GRCh37/hg19
Start
31529565/31561788 (Hg38)
End
31530381/31561788 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
LOC100287329 ; LTA
miRNAs that regulate target gene
hsa-mir-34a-5p
Nearest miRNA
hsa-mir-3143/Upstream/206472; hsa-mir-10398/Downstream/71999;
Nearest TSS
ENST00000381078/Upstream/13361; ENST00000454783/Downstream/10266;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/19669, chr6-CpG: 80/Downstream/18871
Nearby gene
NFKBIL1(No orient, 2959)
Target sequence
GTGTGAGCCACTGCACCTGGCCTATCTTTGTCTCTTTAAGCATCTTCATTTTACCTTCAATTTTATTTCTTGAAAATAAACAACAAAAAAGATCCTTCCTTGGAATATTTCTCCCTCAAATGTCCAGTCTATCTCACCTTCCGTTTTCGTGTGATGTCTCAAAAGACTAGCCCCCTTAACGAACCACTTTTTCAGGAACTGGTAAAATTTCCCTCAACTGTAAAATCTGTGGGTAGAACTAAGAGATGATTCTCA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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