Basic Information
VIS ID
TVIS30000970
Fusion event
HIV-ZER1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.11
Reference genome
GRCh37/hg19
Start
131493386/128731107 (Hg38)
End
131493476/128731107 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
ZER1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-19b-3p ; hsa-mir-615-3p ; hsa-mir-331-3p ; hsa-let-7b-5p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-3692-3p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-4266 ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-6769b-5p ; hsa-mir-6769a-5p ; hsa-mir-92a-2-5p ; hsa-mir-654-5p ; hsa-mir-541-3p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-6878-5p ; hsa-mir-3649 ; hsa-mir-492 ; hsa-mir-661 ; hsa-mir-1827 ; hsa-mir-631 ; hsa-mir-3661 ; hsa-mir-4456 ; hsa-mir-140-3p ; hsa-mir-4779 ; hsa-mir-4695-5p ; hsa-mir-190a-3p ; hsa-mir-1304-3p ; hsa-mir-3613-3p ; hsa-mir-1285-5p ; hsa-mir-5011-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-1277-5p ; hsa-mir-410-3p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-369-3p
Nearest miRNA
hsa-let-7a-1/Upstream/338393; hsa-mir-12126/Downstream/1138498;
Nearest TSS
ENST00000422679/Upstream/6662; ENST00000475097/Downstream/40581;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/6632, chr9-CpG: 91/Downstream/40393
Target sequence
CTTTTCCTTAATGTTAGTGAGATATATATATATTATATATATATATTTTTTTTTTGGTTAGGAATGGTGAAGTTTTGTGTGTATGATTTC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate