Basic Information
VIS ID
TVIS30000977
Fusion event
HIV-DUS2 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
68080654/68046751 (Hg38)
End
68080947/68046751 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA16B
Target gene
DUS2
miRNAs that regulate target gene
hsa-mir-324-3p ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-1262 ; hsa-mir-137 ; hsa-mir-25-3p ; hsa-mir-3194-5p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-4278 ; hsa-mir-4701-3p ; hsa-mir-4710 ; hsa-mir-4711-3p ; hsa-mir-4716-3p ; hsa-mir-511-5p ; hsa-mir-6732-5p ; hsa-mir-6736-5p ; hsa-mir-6747-5p ; hsa-mir-6748-5p ; hsa-mir-6752-5p ; hsa-mir-6755-5p ; hsa-mir-6794-5p ; hsa-mir-6804-5p ; hsa-mir-6805-5p ; hsa-mir-6830-3p ; hsa-mir-6842-5p ; hsa-mir-6858-3p ; hsa-mir-7110-5p
Nearest miRNA
hsa-mir-1225/Upstream/844356; hsa-mir-11401/Downstream/186675;
Nearest TSS
ENST00000527434/Upstream/8747; ENST00000565980/Downstream/31201;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/23301, chr16-CpG: 134/Downstream/37910
Target sequence
GGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAAGCCAAGGCGGGCGGATCACGAGGTCAGGAGATCAAGACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGACGCCTGTAGTCCCAGCTGCTCCGGAGGCTGAGGCAGGAGAATGGCATGAATCCGGCAGGCGGAGCTTGCAGTGAGCCAAGATGGTGCCACTACACTCCAGCCT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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