Basic Information
VIS ID
TVIS30000982
Fusion event
HIV-MRTFA integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
40846152/40450148 (Hg38)
End
40846450/40450148 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
MRTFA
miRNAs that regulate target gene
hsa-mir-183-5p
Nearest miRNA
hsa-mir-1286/Upstream/2461295; hsa-let-7a-3/Downstream/363735;
Nearest TSS
ENST00000624155/Upstream/13838; ENST00000417123/Downstream/13270;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/31050, chr22-CpG: 107/Downstream/185977
Target sequence
GTACCCACTTTAGAGCAGCTATAGATCCCTGGAACTATGTGAATTTTAGGTGCTTGCTTAGACAACTCTGAGAGGATGTGGAAGATTCCCTATGAAGAATATATGGCACAAAAGAAATCAAGAACCTCTGATGTACCAAAGGGTTATTATGACAGAAGAAGAAAGATGCCCATGGCCTTCAAATGAACAGCAACCTGAAAGCACTTGTACTGAAGCGCTTACAAATGACACTTCCACCACCTGATCTCACCAACT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate