Basic Information
VIS ID
TVIS30000984
Fusion event
HIV-PIK3C2A integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
17157232/17135685 (Hg38)
End
17157510/17135685 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
PIK3C2A
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-22-3p ; hsa-mir-21-5p ; hsa-let-7i-5p ; hsa-mir-182-5p ; hsa-mir-26a-5p ; hsa-mir-544a ; hsa-mir-6878-3p ; hsa-mir-378a-5p ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-6778-3p ; hsa-mir-4454 ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3653-5p ; hsa-mir-150-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-212-5p ; hsa-mir-1224-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6813-3p ; hsa-mir-186-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-518a-5p ; hsa-mir-218-1-3p
Nearest miRNA
hsa-mir-210/Upstream/1166064; hsa-let-7a-2/Downstream/1252102;
Nearest TSS
ENST00000527297/Upstream/57898; ENST00000620945/Downstream/34056;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/57726, chr11-CpG: 68/Downstream/71779
Target sequence
CAGGGGATTTAATTAACTTGCTTCATAGAGACATTTATATCTTTAATTGCAAGGATAAAAGAAGGGGTGCATCTCAAAGGCCATGATAAATATAAAGGATAGAAAAGTTACGTTGATGGTGTGCCCCTCGATATCTAGAAGATAACATAGTCCATGCATTCTCAGAAAGATCCTATCCATGTGGTATGTAGAGATGTGGGTTTCTTTTTTTCTACTTTTTTATGTGCTTCTTTTTAGAAACTTATACACACACAC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate