Basic Information
VIS ID
TVIS30000985
Fusion event
HIV-SCAPER integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
77065403/76773062 (Hg38)
End
77066340/76773062 (Hg38)
Orient
+
Location type
Intronic
Target gene
SCAPER
miRNAs that regulate target gene
hsa-mir-218-5p
Nearest miRNA
hsa-mir-10393/Upstream/1010747; hsa-mir-11181/Downstream/2436726;
Nearest TSS
ENST00000557528/Upstream/107404; ENST00000557805/Downstream/2002;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/425580, chr15-CpG: 77/Downstream/131855
Target sequence
ATCAACATTATTTATATGTCAGTCGCCATGGTTTATAATCTTCTTGGCAATATTTATATTAGCATTACTTATGTGTACACTACTCAATCCCACTTATTAAAAAACTCAGTATCATTTTTATAACAAAATCAAAGCTAAAATATGAAGTAAAGACATTAATATGCTAATTCCATCTTTAGAATGACAGTGAAGAAAACAAATATCATTAACTTGGCTGCCATCAGCAGTGAACTTTTATACTGAAAAATTTTAGCA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate