VISDB - VIS Detail

Basic Information

VIS ID

TVIS30000993

Fusion event

HIV-WDR26 integration

Validated

Yes

Detection method

QiaQuick PCR and Sequencing

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

25011556

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr1

Cytoband

q42.11

Reference genome

GRCh37/hg19

Start

224585041/224397339 (Hg38)

End

224586021/224397339 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA1H

Target gene

WDR26

miRNAs that regulate target gene

hsa-mir-140-3p ; hsa-mir-93-5p ; hsa-mir-19b-3p ; hsa-mir-484 ; hsa-mir-30e-5p ; hsa-mir-92a-3p ; hsa-let-7b-5p ; hsa-mir-3200-5p ; hsa-mir-19a-3p ; hsa-mir-5003-3p ; hsa-mir-183-5p ; hsa-mir-548n ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-4635 ; hsa-mir-4282 ; hsa-mir-222-5p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-655-5p ; hsa-mir-4766-5p ; hsa-mir-16-1-3p ; hsa-mir-3065-3p ; hsa-mir-5092 ; hsa-mir-1263 ; hsa-mir-150-3p ; hsa-mir-548aw ; hsa-mir-7641 ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-455-5p ; hsa-mir-4672 ; hsa-mir-466 ; hsa-mir-3941 ; hsa-mir-4790-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-6768-5p ; hsa-mir-5197-3p ; hsa-mir-548l ; hsa-mir-595 ; hsa-mir-4659b-5p ; hsa-mir-4495 ; hsa-mir-4659a-5p ; hsa-mir-708-3p ; hsa-mir-514b-3p ; hsa-mir-514a-3p ; hsa-mir-6809-3p ; hsa-mir-4752 ; hsa-mir-6833-5p ; hsa-mir-489-3p ; hsa-mir-6844 ; hsa-mir-4753-3p ; hsa-mir-8056 ; hsa-mir-3691-5p ; hsa-mir-376c-5p ; hsa-mir-376b-5p ; hsa-mir-3913-3p ; hsa-mir-130b-5p ; hsa-mir-877-3p ; hsa-mir-4687-5p

Nearest miRNA

hsa-mir-101-1/Upstream/140229; hsa-mir-1182/Downstream/888;

Nearest TSS

ENST00000473358/Upstream/20288; ENST00000496372/Downstream/3680;

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/39817, chr1-CpG: 156/Downstream/218596

Target sequence

GTGGGTATTGAAGAAAAATGTGTTGAATAAAAACTTGCAATAATTTGCCACTAGTTAAGTTCCTATCGCCTTAAAAAGTACACTAATTTTTATTACTGCCTCACTTATTTGTGCTTGCATCTTCTAAACAATTCACACTTTAGAGTGACTTTAGGCATATTCCTGTCTGGAATACTGACACTTTTAGATTAGAGAACAAGTTTATTCAAAAGGGTAGTAGTAGGAAGAATAATTTCAGCTTTCCTAAAATCTTAA

Reference

Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.