Basic Information
VIS ID
TVIS30001011
Fusion event
HIV-ZMYND8 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
45857743/47228997 (Hg38)
End
45858488/47228997 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZMYND8
miRNAs that regulate target gene
hsa-mir-548d-5p ; hsa-mir-421 ; hsa-mir-92a-3p ; hsa-mir-18a-5p ; hsa-mir-142-3p ; hsa-mir-3140-3p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/61939; hsa-mir-1-1/Downstream/2634862;
Nearest TSS
ENST00000382410/Upstream/139758; ENST00000599904/Downstream/69903;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/333616, chr20-CpG: 38/Downstream/9913
Target sequence
GAAGCACAATAGCTGAGGTCAGAGATGACACATGAATTTCTTATTTGCTAAGAGTGTTTTGTGGGCTGCTTTAAAGGTGGTACCATGAAGAAGCTTCTCTGGAAACCCCTCTGGGGTCCTGGCTTGGTCACTAAGCTGGCTCTACTGATTGTCATTATCGATGGGGGTATTTTTTCCTTTAGCCAGACGGCTGGGGCTGTGGAGACATGCCCTGCTTTGTGTGATCAATTCATTTCTAATAAAACAGCCAAAATC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate