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Viral Integration Site DataBase
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TVIS30001012
Basic Information
VIS ID
TVIS30001012
Fusion event
HIV-ARHGAP35 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
47493288/46990031 (Hg38)
End
47493756/46990031 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
ARHGAP35
miRNAs that regulate target gene
hsa-mir-296-3p
;
hsa-mir-181b-5p
;
hsa-mir-17-5p
;
hsa-mir-20a-5p
;
hsa-mir-93-5p
;
hsa-mir-106b-5p
;
hsa-mir-20b-5p
;
hsa-mir-519d-3p
;
hsa-mir-574-5p
;
hsa-mir-5010-3p
;
hsa-mir-2113
;
hsa-mir-147a
;
hsa-mir-3611
;
hsa-mir-6818-5p
;
hsa-mir-6867-5p
;
hsa-mir-4670-3p
;
hsa-mir-6749-3p
;
hsa-mir-6763-3p
;
hsa-mir-660-3p
;
hsa-mir-5193
;
hsa-mir-5587-3p
;
hsa-mir-4707-5p
;
hsa-mir-5196-3p
;
hsa-mir-6501-3p
;
hsa-mir-6768-3p
;
hsa-mir-1827
;
hsa-mir-3612
;
hsa-mir-4443
;
hsa-mir-4524a-3p
;
hsa-mir-4722-5p
;
hsa-mir-4768-3p
;
hsa-mir-5091
;
hsa-mir-548aa
;
hsa-mir-548ap-3p
;
hsa-mir-548t-3p
;
hsa-mir-650
;
hsa-mir-6786-3p
;
hsa-mir-6808-5p
;
hsa-mir-6880-5p
;
hsa-mir-6893-5p
;
hsa-mir-7847-3p
;
hsa-mir-940
;
hsa-mir-198
;
hsa-mir-210-3p
;
hsa-mir-6774-3p
;
hsa-mir-4330
Nearest miRNA
hsa-mir-10395/Upstream/280677; hsa-let-7e/Downstream/236911;
Nearest TSS
ENST00000633603/Upstream/447;
ENST00000598548/Downstream/9054;
Nearest CpG islands
None/Target,
chr19-CpG: 112/Upstream/128486
,
chr19-CpG: 40/Downstream/14018
Target sequence
CTGGGTCTTGGCCTGCCAGAGGCACAAAGCAGGAAGGCTGCTGATGACTTAAAAGGTAGTGAGGGCCACATGGTGGGACGCTCTGAGAGGTCAGGCATCCTCTGTGGTACTACACAAAGTCCAGGGAAAGGCTGGCCAGTGAGAAGGCTCGCCCATCTGGACAAACACCTCTACAGAGAGGCAGGCTGGGGCAGGAACAACTGATGAGGCAAGGTGGCATGGCACACAGGATACCATTAAAACCAGAGGTGCTAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Sample Information
×
Sample name
B1
Sample type
PBMC
Gender
Female
CpG Island Information
×
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