Basic Information
VIS ID
TVIS30001015
Fusion event
HIV-CKAP5 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
46829610/46808060 (Hg38)
End
46830543/46808060 (Hg38)
Orient
+
Location type
Exonic
Target gene
CKAP5
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-130b-3p ; hsa-mir-34a-5p ; hsa-mir-103a-3p ; hsa-mir-21-5p ; hsa-mir-18a-5p ; hsa-mir-16-5p ; hsa-mir-484 ; hsa-mir-186-5p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-129-2/Upstream/54868; hsa-let-7a-2/Downstream/371551;
Nearest TSS
ENST00000527297/Upstream/5742; ENST00000531719/Downstream/13197;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/102573, chr11-CpG: 93/Downstream/37583
Target sequence
ATCGCCAGCTTCCAGTTTGGGGTTTTTTATTAGTACTTCTACAGACTCCAGGGCCTCTTTTCTCTCTTGCCATTTTTTTGCCTCCTGCAAGATACAATATGAGTCATTTGTAACAGGAAATAAGAGAGCGGAATAAAAGTCTATTTATTGCACTCTGCTAATTCAAAGATACATAATTTTTTTAAAAAATTATAAAACTGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGAGGG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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