Basic Information
VIS ID
TVIS30001019
Fusion event
HIV-NSF integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
44759886/46682520 (Hg38)
End
44760808/46682520 (Hg38)
Orient
-
Location type
Intronic
Target gene
NSF
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-103a-3p ; hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-877-3p ; hsa-mir-193b-3p ; hsa-mir-100-5p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-205-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1180/Upstream/1207085; hsa-mir-10226/Downstream/290497;
Nearest TSS
ENST00000595228/Upstream/58484; ENST00000576346/Downstream/30629;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/91353, chr17-CpG: 42/Downstream/87253
Target sequence
ATTTGTGCACCAAATTTTCTTGATATAGTTTAAAAGTAGACAGATGCTGAAGGCAGGTATTACAGAGAGATAGCCAGAAGAAATAGATGAAGTAGACATTAAAAAATTGGATTGACCATAAAAAACAGAATTGATCATTCTGAAAGGTATCTACAAATCTAAAAATAAAAATGTTTTGCAACTGTGGAACATATAATGGTCATCCTCTCTTCAACAAAATTAGGAGCCAAAGATCTCAAAAAAATTCTTAAAGCA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate