Basic Information
VIS ID
TVIS30001020
Fusion event
HIV-OLFM2 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
9979158/9868482 (Hg38)
End
9979637/9868482 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
OLFM2
Nearest miRNA
hsa-mir-1227/Upstream/1479102; hsa-let-7e/Downstream/169872;
Nearest TSS
ENST00000633603/Upstream/10314; ENST00000592332/Downstream/45354;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/13725, chr19-CpG: 166/Downstream/44677
Target sequence
AGGCGTGAGGCACTGTGTCCAGCCAATTTACAAATTTAAGATGCATCTACAGAATGAGATACTATGCAGTCATTAAAAATTAGAGATTAATGGAGATTTTAATCACCATCTTTAAATTTATCTTATTTTCCAAGTTTTCTACAATGAACGTGTATTGTTCTTATAAAGATTTTTAGGGCCGGGTGCAGTGGCTCACGCTTGTAATCCCAACACTTTGGGAAGCCAAGGCAGGAGAATCACTTGAGCCCAGGAGTT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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