Basic Information
VIS ID
TVIS30001021
Fusion event
HIV-PDE3B integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
14721457/14699911 (Hg38)
End
14722297/14699911 (Hg38)
Orient
-
Location type
Intronic
Target gene
PDE3B
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-128-3p ; hsa-mir-124-3p ; hsa-mir-93-5p ; hsa-mir-16-5p ; hsa-mir-562 ; hsa-mir-3119 ; hsa-mir-4735-5p ; hsa-mir-5683
Nearest miRNA
hsa-mir-210/Upstream/2536144; hsa-let-7a-2/Downstream/1269622;
Nearest TSS
ENST00000527297/Upstream/1072; ENST00000525439/Downstream/89028;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/54783, chr11-CpG: 68/Downstream/191443
Target sequence
ATATCCTGATATCTACAATAGGAGAATAAGCTCACTCTTGGGAGATACTGCTTGCAACGGCTTCCCACACCTACTGCCACTTGAACATCAGAAAAACACTGAGGAAAAAGGGAAAATTTTCATTTAGAGGAAAACACACATTTGAAATTTAAGTAACCTTTTTTTAATTCAGCAAATGTTTTGAAAAATAATACCCTAAATATGGGGGAAACTGGCATGCCTTTTCTATACTTGTTTTAATGGCATTATACTTTG
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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