Basic Information
VIS ID
TVIS30001024
Fusion event
HIV-RPRD1B integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
36699159/38070757 (Hg38)
End
36700025/38070757 (Hg38)
Orient
-
Location type
Intronic
Target gene
RPRD1B
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-124-3p ; hsa-mir-103a-3p ; hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-mir-33a-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-3944-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-504-3p ; hsa-mir-545-3p ; hsa-mir-6838-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/2616660; hsa-mir-1-1/Downstream/445806;
Nearest TSS
ENST00000382410/Upstream/4576; ENST00000484683/Downstream/13139;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/36664, chr20-CpG: 35/Downstream/94390
Target sequence
GAAAACAGTCTGATGGTTCCTCAAAATGTTACATAGAATTACCATATGACCCAGCAATTCCACTCCTAGATTTATACATAACCAAGAGAAATGAAAAGATATGGCCACACAAAAACCTCCACATGACTGTTTATAGCAACACTATTCATAAGAGCCAAAAGGTGGAAACAACTCAAATGTCCATAGACAGGTTATAAACTGTGTCACATCCATACAACAGATTAGTGTTCTACCATAAAAGAGATGAAGTACTGA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate