Basic Information
VIS ID
TVIS30001036
Fusion event
HIV-PDXDC1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
15102669/15008812 (Hg38)
End
15103586/15008812 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA16A
Target gene
PDXDC1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-615-3p ; hsa-mir-222-3p
Nearest miRNA
hsa-mir-1225/Upstream/77933; hsa-mir-11401/Downstream/1509;
Nearest TSS
ENST00000527434/Upstream/11064; ENST00000561930/Downstream/499;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/18505, chr16-CpG: 80/Downstream/46535
Target sequence
TTCCTCGCTCTATATCATCTTTAATCAGTTTCTCCAGGAAGGCAACATCCTGGAACCAAAACAAATCATTAAAAAATGAGGTGCCCAGTATAAAAGCTATAAAATGAAAAATTATGACTTACAAAAGAAGCAGATAACTCTCAAAAGTAATGTCAAATCAATTCTTACTCTTGACAATTTTTCTGTTTTCTCTCATCATAGATGTGAAAATCAAATAGTTTTCCTTGAAGACTAGAAAAATCAGTTAAACAAAAT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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