Basic Information
VIS ID
TVIS30001037
Fusion event
HIV-PHYKPL integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q35.3
Reference genome
GRCh37/hg19
Start
177647872/178220871 (Hg38)
End
177648796/178220871 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
PHYKPL
miRNAs that regulate target gene
hsa-mir-4266 ; hsa-mir-1229-5p ; hsa-mir-1258 ; hsa-mir-6769b-5p ; hsa-mir-6769a-5p ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-3132 ; hsa-mir-197-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-765 ; hsa-mir-6732-5p ; hsa-mir-4695-5p ; hsa-mir-4779 ; hsa-mir-1179
Nearest miRNA
hsa-mir-10397/Upstream/1591371; hsa-mir-1229/Downstream/1577407;
Nearest TSS
ENST00000502646/Upstream/15303; ENST00000521803/Downstream/1605;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/15364, chr5-CpG: 84/Downstream/11325
Target sequence
ATATGTTAGTAGAAAAAAAAATCCCCAGAGTATATACAGCATGATAGACTTCATATAAAGTCAAATAACAACTAAATAATATGGGATTGAGAGTGATGGTTACCATGGTTATTCAGAGTGATGGGTGGAGAAGGCAACAAGAGGGAATTGGGGGGAACATCTGGAGAGATACATGATATTATCAAGGTCTAAGCTTTCATTAGGGATGCTGGCTTCCCAGGTGCTTAGAACATTAATAAAGGTTAACTGAATAAC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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